Fetal MRI study of brain differences in early-onset fetal growth restriction versus healthy controls at 30 weeks of gestation.

ABSTRACT:

Objective

To identify volumetric and diffusion-related brain differences expressed as apparent diffusion coefficient (ADC) values between early-onset brain-sparing fetal growth restriction (FGR) and healthy controls using magnetic resonance imaging (MRI) at 30 weeks of gestation.

Method

This prospective, observational, monocenter cohort study included singleton pregnancies with early-onset brain-sparing FGR at the University Medical Center Utrecht. FGR fetuses were compared to healthy controls from the Utrecht YOUth Cohort. Fetal MRI of the brain was performed including T2-weighted and diffusion weighted imaging (DWI) sequences. We measured 2D biometrics, 3D volumetrics using BOUNTI, and ADC values in multiple brain and placental regions. Values were corrected to 30 weeks of

SUBMITTER: Meijerink L 

PROVIDER: S-EPMC12275939 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature