Thyroid dysfunction and pulmonary arterial hypertension: A bidirectional mendelian randomization study.

ABSTRACT:

Objective

Thyroid dysfunction can cause several cardiovascular diseases. Studies have suggested a link between thyroid dysfunction and an increased risk of Pulmonary Arterial Hypertension (PAH). However, the causal association between this link is unknown. The aim of this study was to investigate the causal association between thyroid dysfunction and PAH using bidirectional two-sample Mendelian Randomization (MR) analysis.

Method

Thyroid dysfunction (Free triiodothyronine (FT3), free thyroxine (FT4), thyrotropin (TSH), hyperthyroidism and hypothyroidism) and PAH were respectively used as exposure and outcome factors. The bidirectional causal association between thyroid dysfunction and PAH was analyzed by using Inverse Variance Weighting (IVW), MR-Egger regression (MR-Egger),

SUBMITTER: Pang G 

PROVIDER: S-EPMC12275978 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature