Respiratory infections in pregnancy and early life-association with the development of islet autoimmunity and type 1 diabetes in children: systematic review and meta-analysis of observational studies.

ABSTRACT:

Background

Respiratory tract infections (RTIs) in pregnancy and early childhood are potential environmental triggers of islet autoimmunity (IA) and type 1 diabetes (TD). We reviewed the association between gestational and childhood RTIs and the development of IA or T1D in the offspring.

Methods

Systematic review and meta-analysis, analysed using random effects models, of observational human studies from Medline and EMBASE, without language restriction, from inception until Jan 6, 2025. The inclusion criteria were cohort, case-control, nested case control or retrospective cohort studies investigating confirmed RTI in childhood or pregnancy by reported history or detection by throat swab before/at IA seroconversion and/or T1D diagnosis in children aged < 18 years. The study is

SUBMITTER: Sung CJ 

PROVIDER: S-EPMC12275980 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature