BAHCC1 promotes gene expression in neuronal cells by antagonizing SIN3A-HDAC1.

ABSTRACT: Chromatin modifications play a key role in regulating gene expression during development and adult physiology. Histone acetylation, particularly H3K27ac, is associated with increased activity of gene regulatory elements such as enhancers and promoters. However, the regulation of the machinery that writes, reads, and erases this modification remains poorly understood. In particular, the SIN3A-HDAC1 complex possesses histone deacetylase activity, yet it commonly resides at active regulatory regions. Here, we study BAHCC1, a large chromatin-associated protein essential for viability and recently reported to play a largely repressive role. We show that in neuronal lineage cells, BAHCC1 is mainly associated with regulatory elements marked with H3K27ac. BAHCC1 interacts and co-occupies shared ge

SUBMITTER: Monziani A 

PROVIDER: S-EPMC12276004 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature