Synthesis and Biological Evaluation of Bicyclic Pyrazolines with Promising Antimicrobial Activities.

ABSTRACT: The efficient photochemical synthesis of bicyclic pyrazolines using flow technology as well as the subsequent antimicrobial evaluation of these scaffolds is reported. Low minimal inhibitory concentration values of 0.5-4 μg mL^-1 are found against a series of multidrug resistant bacterial strains including different Staphylococcus and Enterococcus genera species. The lead compound, which is decorated by a halogenated aryl ring system, appears to be bacteriostatic and shows excellent physicochemical and pharmacokinetic properties. Due to low levels of predicted toxicity combined with a high level of drug-likeness, these bicyclic pyrazolines therefore are promising candidates for further studies as antibacterial species.

SUBMITTER: Caviglia D 

PROVIDER: S-EPMC12276031 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature