Millisecond Phase Transition Kinetics of Lyotropic Liquid Crystalline Nanoparticles Observed by Time-Resolved Small Angle X-ray Solution Scattering.

ABSTRACT: This study investigates the dynamic behavior of lyotropic liquid crystal nanoparticles (LCNPs), which are widely recognized for their applications in drug delivery. By employing nanosecond near-infrared laser pulse-induced temperature jump (T-jump) and time-resolved X-ray solution scattering, the structural dynamics of phase transitions in phytantriol-based cubosomes and hexosomes are revealed. Both cubosome and hexosome LCNPs undergo phase transitions into noncrystalline phases at high temperatures. Their phase transition kinetics, occurring within milliseconds (ms) and involving one intermediate structure, are captured. Additionally, the reverse self-assembly processes of LCNPs were observed, occurring on the timescale of a few hundred ms. To our knowledge, this is the first observation

SUBMITTER: Lee C 

PROVIDER: S-EPMC12276034 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature