Prognostic impact of multi-domain approaches and the Tilburg frailty indicator in elderly patients with heart failure.

ABSTRACT:

Backgrounds

The optimal multidimensional frailty assessment approach in heart failure (HF) remains uncertain. This study aimed to compare the prognostic value of a multi-domain approach versus the Tilburg Frailty Indicator (TFI) in elderly HF patients.

Methods

This prospective single-center cohort study consecutively enrolled 461 elderly HF patients at Fuzhou University Affiliated Provincial Hospital, China. Frailty was assessed using both the TFI and a multi-domain approach. The primary outcome was the composite of heart failure hospitalization or all-cause death within six months. Clinical outcomes were analyzed using Kaplan-Meier and Cox proportional hazards regression models, with predictive performance compared by receiver operating characteristic curves.

Results

SUBMITTER: Guo X 

PROVIDER: S-EPMC12276110 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature