Comparison of the quantification performance of thermal desorption GC-IMS and GC-MS in VOC analysis.

ABSTRACT: Accurate and reproducible quantification of volatile organic compounds (VOCs) is essential in environmental monitoring, clinical diagnostics, and quality control. Thermal desorption gas chromatography (TD-GC) is widely used for VOC analysis, often coupled with mass spectrometry (MS) for reliable identification. Ion mobility spectrometry (IMS) has gained attention for its high sensitivity and rapid detection. While GC-IMS and GC-MS are well established, TD-GC coupled to both IMS and MS has not been systematically investigated. This study presents a comprehensive assessment of a TD-GC-MS-IMS system, combining the strengths of both detectors. A mobile flow- and temperature-controlled sampling unit for TD tubes was developed for standardized applications, designed to introduce both gaseous and

SUBMITTER: Schanzmann H 

PROVIDER: S-EPMC12276119 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature