Integrative bioinformatics analysis identifies METTL1 as a regulator of immune infiltration and prognosis in breast cancer.

ABSTRACT: To explore the role of Methyltransferase-like 1 (METTL1) in the prognosis, diagnosis, and immune infiltration of Breast invasive carcinoma (BRCA), transcriptome data of BRCA from The Cancer Genome Atlas (TCGA) database were analyzed. Then, the METTL1 expression in normal and cancer tissues was compared using the DESeq2 package. Next, the diagnostic and prognostic value of METTL1 was evaluated using receiver operating characteristic curves and survival analysis, respectively. Co-expressed genes and differentially expressed genes related to METTL1 were identified using Pearson correlation and Wilcoxon tests, with overlapping genes subjected to protein-protein interaction network construction to identify hub genes via degree algorithm. After that, immune infiltration analyses were performed u

SUBMITTER: Lin XB 

PROVIDER: S-EPMC12276251 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature