Cardiac MRI of differing ischemia and reperfusion times in a myocardial infarction pig model.

ABSTRACT: The closed-chest porcine model of myocardial ischemia is an essential tool for preclinical research in cardiology. Current literature reports heterogeneous results regarding myocardial ischemia and reperfusion injury (IRI). This retrospective analysis presents our experience and cardiac magnetic resonance (CMR) findings while establishing a porcine IRI model. 8 male and 12 female juvenile German Landrace pigs received general anesthesia and antiarrhythmic pre-treatment. Myocardial ischemia was induced using transfemoral catheterization and balloon-occlusion of the left anterior descending (LAD) or the left circumflex (LCX) coronary artery under X-ray fluoroscopy guidance. The duration of ischemia varied from 30 to 90 min. CMR was performed at a clinical 3 T system including functional imag

SUBMITTER: Boll D 

PROVIDER: S-EPMC12276265 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature