Bioinformatics analysis identifies NT5M modulates immune evasion through PD-L1 via CXCL8 in pancreatic adenocarcinoma.

ABSTRACT: Pancreatic adenocarcinoma (PAAD) is a highly aggressive and lethal malignancy, characterized by late diagnosis, rapid progression, and poor response to conventional therapies. Altered nucleotide metabolism has recently been recognized as a critical driver of tumorigenesis, impacting cellular proliferation, invasion, and immune evasion. However, the role of specific metabolic enzymes, such as NT5M (cytosolic 5'-nucleotidase, mitochondrial), in PAAD remains poorly understood. In this study, we employed an integrated approach combining comprehensive bioinformatics analysis with systematic in vitro functional assays to investigate the multifaceted roles of NT5M in PAAD. Our investigation focused on three key aspects: (1) establishing NT5M as a novel prognostic biomarker, with lower expression

SUBMITTER: Zhai C 

PROVIDER: S-EPMC12276275 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature