Chronic circadian disruption in adolescent mice impairs hippocampal memory disrupting gene expression oscillations.

ABSTRACT: Chronodisruption, the misalignment of internal biological systems with external environmental changes, negatively impacts health and cognition. A prevalent form, social jet lag, affects a large portion of adolescents and is associated with reduced academic performance, and impaired emotional regulation. Despite its prevalence, the mechanism by which adolescent chronodisruption results in cognitive deficits remains unexplored. Here, we induced chronic chronodisruption in adolescent mice through light/dark cycle manipulation. We performed a battery of established behavioral tests alongside an analysis of daily rhythms of expression of genes involved in relevant physiological functions. We report that adolescent circadian disruption induces impairments in short-term, social, and spatial memor

SUBMITTER: Gallego-Landin I 

PROVIDER: S-EPMC12276311 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature