Single-cell transcriptome analyses reveal the mechanism of mitochondrial activity in erectile dysfunction.

ABSTRACT:

Background

Erectile dysfunction (ED) is a multifactorial disorder, with mitochondrial dysfunction increasingly recognized as an important contributor to its pathogenesis.

Aim

This study aimed to characterize the single-cell landscape of ED and investigate the impact of mitochondrial function on cellular heterogeneity.

Methods

We performed single-cell RNA sequencing analysis on ED samples (GSE206528), screened for ED-related mitochondrial genes, evaluated mitochondrial activity using area under the curve cell scoring at the single-cell level, and conducted subclustering, cell-cell communication, pseudotime trajectory, and pathway enrichment analyses to systematically characterize key cell populations.

Outcomes

The principal finding is that fibroblasts (FB) and e

SUBMITTER: Xiao B 

PROVIDER: S-EPMC12276377 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature