Long-term effectiveness, safety, and liver stiffness dynamics of PBC treatment with obeticholic acid in real-world.

ABSTRACT:

Background & aims

Several studies have assessed the short-term effectiveness and safety of obeticholic acid (OCA) in the real-world setting. We aimed to extend knowledge on the real-world effectiveness and safety of OCA treatment by expanding sample size and follow-up, and by exploring changes in liver stiffness measurement (LSM) over time.

Methods

The RECAPITULATE project involves centres belonging to the "Italian PBC registry" and/or the "Club Epatologi Ospedalieri" PBC working group. Effectiveness was evaluated as biochemical response according to POISE and normal range (NR) criteria (normal alkaline phosphatase/alanine aminotransferase/bilirubin). Safety was assessed as the incidence of de novo/worsening pruritus and discontinuation rate/causes. Available LSMs wer

SUBMITTER: Terracciani F 

PROVIDER: S-EPMC12276448 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature