Exercise's protective role in chronic obstructive pulmonary disease via modulation of M1 macrophage phenotype through the miR-124-3p/ERN1 axis.

ABSTRACT: ObjectiveChronic obstructive pulmonary disease is a leading cause of global mortality. Although exercise training improves lung function and quality of life in chronic obstructive pulmonary disease patients, its mechanisms remain unclear. This study aims to reveal the effects of exercise on chronic obstructive pulmonary disease and elucidate the underlying molecular mechanisms involved.MethodsThis pre-post observational cohort study included 11 chronic obstructive pulmonary disease patients who underwent a 12-week exercise training program to evaluate the effects of exercise intervention. A cigarette smoke-induced chronic obstructive pulmonary disease mouse model and a cigarette smoke extract-induced bronchial endothelial cell model were utilized to investigate the protective mechanisms of

SUBMITTER: Zeng H 

PROVIDER: S-EPMC12276488 | biostudies-literature | 2025 Jul-Sep

REPOSITORIES: biostudies-literature