Imaging-Based Molecular Characterization of Adult-Type Diffuse Glioma Using Diffusion and Perfusion MRI in Pre- and Post-Treatment Stage Considering Spatial and Temporal Heterogeneity.

ABSTRACT:

Background

Imaging-based molecular characterization is important for identifying treatment targets in adult-type diffuse gliomas.

Purpose

To assess isocitrate dehydrogenase (IDH) mutation and epidermal growth factor receptor (EGFR) amplification status in primary and recurrent gliomas using diffusion and perfusion MRI, addressing spatial and temporal heterogeneity.

Study type

Retrospective.

Subjects

Three-hundred and twelve newly diagnosed (cross-sectional set, 57.9 ± 13.2 years, 52.2% male, 235 IDH-wildtype, 71 EGFR-amplified) and 38 recurrent (longitudinal set, 53.1 ± 13.4 years, 44.7% male, 30 IDH-wildtype, 13 EGFR-amplified) adult-type diffuse glioma patients.

Field strength/sequence

3.0T; diffusion weighted and dynamic susceptibility contrast-perfus

SUBMITTER: Roh YH 

PROVIDER: S-EPMC12276639 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature