Early-onset difficult-to-treat rheumatoid arthritis: proposal of data-driven predictors and temporal threshold.

ABSTRACT:

Background

While risk factors for difficult-to-treat rheumatoid arthritis (D2TRA) have been studied in recent years, no studies have determined if there are differences between early and late developers of D2TRA. This study investigates whether patients can be classified by time to D2TRA development and examines risk factors for earlier onset.

Patients and methods

Observational study involving D2TRA patients whose reason for switching b/tsDMARD therapy was inefficacy (D2TRA-Inneficacy). Demographic data, comorbidities and disease characteristics, acute phase reactants and Disease Activity Score-28 [DAS28-ESR]) at baseline and 6 months after initiation of the first b/tsDMARD, and duration of each treatment were recorded. Using LASSO (Least Absolute Shrinkage and Selection Ope

SUBMITTER: Rodriguez-Merlos P 

PROVIDER: S-EPMC12276655 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature