Imaging features and prognostic significance of immune checkpoint inhibitor-related pneumonitis in NSCLC.

ABSTRACT:

Background

Immune checkpoint inhibitors (ICIs) have demonstrated substantial therapeutic efficacy in the treatment of non-small cell lung cancer (NSCLC); however, their clinical application is associated with unique immune-related adverse effects (irAEs). Among these adverse events, immune checkpoint inhibitor-related pneumonitis (CIP) is rare yet serious, which may potentially result in severe respiratory failure, thereby requiring close clinical monitoring. Research specifically focusing on CIP in NSCLC patients treated with PD-1 inhibitors remain limited. This study targets this distinct cohort to comprehensively investigate the clinical and radiological determinants associated with overall survival, applying time-dependent covariate Cox regression to capture the dynamic impact

SUBMITTER: Wang X 

PROVIDER: S-EPMC12276695 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature