The spinal premotor network driving scratching flexor and extensor alternation.

ABSTRACT: Rhythmic motor behaviors are generated by neural networks termed central pattern generators (CPGs). Although locomotor CPGs have been extensively characterized, it remains unknown how the neuronal populations composing them interact to generate adaptive rhythms in mammals. We explored the cooperation dynamics among the three main populations of ipsilaterally projecting spinal CPG neurons-V1, V2a, and V2b neurons-in scratch reflex rhythmogenesis. Individual ablation of the three neuronal populations reduced the oscillation frequency. Activation of excitatory V2a neurons enhanced the oscillation frequency, while activating inhibitory V1 neurons suppressed movement. Building on these findings, we developed a neuromechanical model made of self-oscillating flexor and extensor modules coupled vi

SUBMITTER: Yao M 

PROVIDER: S-EPMC12277023 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature