Bitter taste receptor agonists induce vasorelaxation in porcine coronary arteries.

ABSTRACT:

Background

Ischemic heart disease (IHD) remains a leading cause of global morbidity and mortality, necessitating the search for novel therapeutic approaches. Recent studies have identified bitter taste receptors (TAS2Rs) in vascular smooth muscle cells as potential therapeutic targets because of their vasorelaxant properties. This study investigated the vasorelaxant effects of TAS2R agonists on porcine coronary arteries ex vivo and explored their potential as novel therapeutic targets for IHD.

Methods

Isolated porcine coronary artery rings were precontracted using U46619 and treated with TAS2R agonists, including flufenamic acid, dapsone, phenanthroline, chloroquine, and quinine. Vasorelaxation induced by TAS2R agonists was quantitatively assessed, and pharmacological

SUBMITTER: Tsai CC 

PROVIDER: S-EPMC12277086 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature