A novel vasculogenic mimicry-related nomogram predicts prognosis in hepatocellular carcinoma.

ABSTRACT:

Objective

Hepatocellular carcinoma (HCC) is the most common type of liver cancer and has a poor prognosis. Vasculogenic mimicry (VM) is an angiogenic process associated with the growth and spread of malignant tumors. In this study, we aim to create a VM-related, gene-based prediction model to evaluate the prognosis and immune infiltration in HCC patients.

Materials and methods

A total of 364 patients from the TCGA database and 242 patients from the GEO database with complete clinical information and transcriptome sequencing data were enrolled in this study. LASSO Cox regression analysis was performed to identify VM-related hub genes. Biological process (BP), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, and gene set enrichment analysis (GSEA) were appli

SUBMITTER: Zhong Y 

PROVIDER: S-EPMC12277141 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature