Prognostic value of the lactate dehydrogenase to albumin ratio in cancer patients.

ABSTRACT:

Objective

This study aimed to explore the prognostic relevance of the lactate dehydrogenase-to-albumin ratio (LAR) in cancer patients.

Methods

A comprehensive literature search was conducted across PubMed, EMBASE, and the Cochrane Library for studies published before March 15, 2025. The primary outcomes included pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for overall survival (OS), progression-free survival (PFS), and recurrence-free survival (RFS). In addition, a retrospective cohort of 71 hepatocellular carcinoma (HCC) patients treated with immune checkpoint inhibitors at our institution was analyzed to assess the prognostic impact of baseline LAR on OS and PFS.

Results

Eighteen studies comprising 8,335 patients were incorporated into

SUBMITTER: Chai D 

PROVIDER: S-EPMC12277156 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature