Association of circulating 25-hydroxyvitamin D with time in range and insulin secretion in type 2 diabetes.

ABSTRACT:

Background

To explore the association of circulating 25-hydroxyvitamin D [25(OH)D] with time in range and insulin secretion in type 2 diabetes.

Methods

911 patients diagnosed with type 2 diabetes mellitus (T2DM) were included, and they underwent 3-day continuous glucose monitoring (CGM) and serum 25(OH)D measurements. The subjects were categorized into three groups based on the tertiles of their serum 25(OH)D levels: G1 (25(OH)D ≤ 21.22 ng/mL), G2 (21.22 ng/mL ≤ 25(OH)D < 26.43 ng/mL), and G3 (25(OH)D ≥ 26.43 ng/mL). TIR and glycemic variability (GV) parameters were evaluated with CGM. Insulin resistance was evaluated via the homeostatic model assessment of insulin resistance (HOMA-IR). The pancreatic β-cell function was determined using the homeostasis model assessment of β

SUBMITTER: Jiang W 

PROVIDER: S-EPMC12277161 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature