Discovery of influenza-like virus clades in invertebrates and the evolutionary history and host-shifting events of Orthomyxoviridae in metazoans.

ABSTRACT: Epidemics are often initiated by emerging and re-emerging infectious diseases caused by viruses of animal origin. It is thus important to identify the reservoirs of potentially zoonotic viruses and understand the dynamics of their host shifts. The flu viruses belong to the virus family Orthomyxoviridae, which also contains Isavirus, Quaranjavirus, and Thogotovirus. Many members of this virus family are known to be pathogenic to humans. For initial surveillance of animal-originated or zoonotic Orthomyxoviridae, unclassified viruses were screened by the use of high-throughput transcriptomes as a data source because of their wide species and lineage coverage. We identified 96 novel or unclassified Orthomyxoviridae members with the discovery of three new lineages of the virus, possibly new gen

SUBMITTER: Leung RWT 

PROVIDER: S-EPMC12277240 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature