Vagal nerve signals are modulated by spontaneous seizures in Genetic Absence Epilepsy Rats from Strasbourg.

ABSTRACT:

Introduction

One-third of epileptic patients are resistant to conventional treatments. Vagus nerve stimulation is a promising therapy, especially when applied early during seizure onset. This study explores vagus nerve activity (VNA) during seizures in Genetic Absence Epilepsy Rat from Strasbourg (GAERS) model and explores how VNA changes with epilepsy duration.

Methods

Eleven rats (4, 6, and 10 months old, n = 4, 4, 3, respectively) were continuously recorded with electroencephalography, VNA recordings, and video for 24 h. Ictal VNA root mean square (RMS) values preceded by NREM sleep extracted from 11 rats were studied in a total of 620 seizures.

Results

Overall, VNA RMS increased during seizures, with a median rise of 60%. However, this modulation decreased

SUBMITTER: Collard E 

PROVIDER: S-EPMC12277265 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature