Genomic characterization of <i>Vibrio cholerae</i> isolated from clinical and environmental sources during the 2022-2023 cholera outbreak in Kenya.

ABSTRACT:

Background

Cholera remains a public health challenge in Kenya. To better understand its dynamics, we analyzed Vibrio cholerae genomes from clinical and environmental samples collected during the 2022-2023 outbreak. These strains were compared with historical genomes from Kenya, Uganda, Tanzania, and Haiti to inform strategies for cholera prevention, control, and elimination in Kenya.

Methods

Clinical (stool) and environmental (wastewater, drinking water, and household effluent) samples were collected from Nairobi county. Samples were analyzed for V. cholerae using culture and real time PCR. The environmental (n = 17) and clinical (n = 70) isolates were then subjected to phenotypic antimicrobial susceptibility testing using the Kirby-Bauer disk dif

SUBMITTER: Mageto LM 

PROVIDER: S-EPMC12277283 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature