Resolving inconsistent effects of tDCS on learning using a homeostatic structural plasticity model.

ABSTRACT:

Introduction

Transcranial direct current stimulation (tDCS) is increasingly used to modulate motor learning. Current polarity and intensity, electrode montage, and application before or during learning had mixed effects. Both Hebbian and homeostatic plasticity were proposed to account for the observed effects, but the explanatory power of these models is limited. In a previous modeling study, we showed that homeostatic structural plasticity (HSP) model can explain long-lasting after-effects of tDCS and transcranial magnetic stimulation (TMS). The interference between motor learning and tDCS, which are both based on HSP in our model, is a candidate mechanism to resolve complex and seemingly contradictory experimental observations.

Methods

We implemented motor learning and tDC

SUBMITTER: Lu H 

PROVIDER: S-EPMC12277285 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature