The kynurenine pathway as a potential link between ethanol-induced behavioral alterations and neuroinflammation.

ABSTRACT:

Introduction

The neuroimmune actions of ethanol have recently gained significant attention. Concurrently, the kynurenine pathway, the main catabolic route of tryptophan (TRP), has emerged as a novel target for modulating drug abuse and as a critical immune regulator. This pathway is implicated in behavioral and cognitive alterations, including anxiety, depression, and memory impairment-conditions closely associated with ethanol (EtOH) dependence. The kynurenine pathway is activated under inflammatory and immune conditions.

Objective

We previously demonstrated that chronic EtOH consumption increases kynurenine (KYN) levels in mice. Here, we investigate the effect of EtOH dependence and withdrawal on behavioral and cognitive parameters, the nucleus accumbens (NAc) transcriptom

SUBMITTER: Gil de Biedma-Elduayen L 

PROVIDER: S-EPMC12277286 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature