Targeting ERRs to counteract age-related muscle atrophy associated with physical inactivity: a pilot study.

ABSTRACT:

Introduction

Estrogen-related receptors has been suggested as a potential therapeutic target to counteract muscle decline associated with aging or inactivity, being known to regulate mitochondrial function and cellular respiration by up-regulating key factors in muscle responses to exercise. This study aimed to evaluate the targeting of ERRs in myoblasts isolated from the skeletal muscle of inactive women by assessing the metabolic and expression changes associated with its activation.

Methods

Twenty women undergoing hip arthroplasty for coxarthrosis were enrolled and divided into an active group (n = 10) and an inactive group (n = 10) based on self-reported physical activity. During surgery, muscle biopsies were taken for histological and western blotting analysis, measurin

SUBMITTER: Bonanni R 

PROVIDER: S-EPMC12277287 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature