Exploration of the potential neurotransmitter or neuromodulator-like properties of harmine: evidence from synthesis to synaptic modulation.

ABSTRACT:

Background

The discovery of new neurotransmitters is crucial for the in-depth understanding of neural signal transmission, neurological disorders, and relevant treatment strategies. Emerging evidence has indicated that harmine is an important endogenous compound, and its level is closely related to different physiological and disease states. Inspired by this, we propose a hypothesis that harmine may be a potential neurotransmitter or neuromodulator and display neurotransmitter or neuromodulator-like properties. This study aims to explore the potential properties of harmine as a neurotransmitter or neuromodulator according to the essential criteria for neurotransmitters and neuromodulators.

Methods

Candidate proteins for the biosynthesis of harmine were searched by local BLAS

SUBMITTER: Xie Z 

PROVIDER: S-EPMC12277293 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature