Development and validation of a multidimensional predictive model for 28-day mortality in ICU patients with bloodstream infections: a cohort study.

ABSTRACT:

Background

Bloodstream infections (BSI) are a leading cause of sepsis and death in intensive care unit (ICU). Traditional severity scores, including the Sequential Organ Failure Assessment (SOFA), Acute Physiology Score III (APSIII), and Simplified Acute Physiology Score II (SAPS II), exhibit limitations in effectively predicting mortality among BSI patients, primarily due to their reliance on a narrow range of clinical variables. This study aimed to develop and validate a comprehensive nomogram model for 28-day all-cause mortality prediction in BSI patients.

Methods

A retrospective cohort study was conducted using data from 3,615 patients with positive blood cultures from the MIMIC-IV database, divided into training (n=2,532) and validation (n=1,083) cohorts. Through a two-

SUBMITTER: Jin J 

PROVIDER: S-EPMC12277296 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature