Innate immune role of IL-6 in influenza a virus pathogenesis.

ABSTRACT: Interleukin-6 (IL-6), a pleiotropic cytokine, is induced by infection of influenza A virus (IAV), where it plays a pivotal role in immune defense and the regulation of inflammation. IAV induces IL-6 transcription upon recognition by pattern recognition receptors, which activate downstream signaling cascades, leading to the activation of transcription factors. Activated transcription factors subsequently regulate the expression of IL-6 in innate immune cells, such as macrophages, dendritic cells, and epithelial cells. IL-6 contributes to antiviral immunity by promoting the recruitment of immune cells to sites of infection and amplifying the inflammatory response. While optimal IL-6 production is essential for effective anti-IAV immunity, excessive IL-6 production can contribute to a dysregu

SUBMITTER: Li X 

PROVIDER: S-EPMC12277322 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature