The efficacy and safety of neoadjuvant and adjuvant chemo(radio)therapy combined with surgery in patients with locally advanced rectal cancer harboring defective mismatch repair system: a large-scale multicenter propensity score analysis.

ABSTRACT:

Background

For locally advanced rectal cancer (LARC) with a deficient mismatch repair/microsatellite instability-high (dMMR/MSI-H), particularly in patients not eligible for immunotherapy, the optimal treatment remains undetermined. This study was to evaluate the efficacy and safety of surgery, surgery and chemotherapy, surgery and chemoradiotherapy, in patients with LARC harboring dMMR/MSI-H.

Methods

Patients included from three university centers between August 1, 2012 and March 1, 2023, were categorized into three treatment groups: surgery vs. surgery + chemotherapy vs. surgery + chemoradiotherapy. The primary endpoint was overall survival (OS), with secondary endpoints of progression-free survival (PFS), local recurrence (LR), distant metastasis (DM), and t

SUBMITTER: Wang HH 

PROVIDER: S-EPMC12277327 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature