A longitudinal metabolomics study on blood mercury and depressive symptoms.

ABSTRACT: Mercury exposure may increase the risk of depression. This study examined associations between blood mercury, depressive symptoms (PHQ-9), and metabolomic pathways in Chinese young adults. Fasting venous blood samples and questionnaire data (N = 477) were collected from the Chinese undergraduate cohort study in 2019 and 2021. Patient Health Questionnaire-9 was used to estimate depressive symptoms. Blood mercury and serum metabolomic were measured using inductively coupled plasma mass spectrometry (ICP-MS) and liquid chromatography-mass spectrometry (LC-MS). The association between whole-blood mercury concentrations and depressive symptoms were assessed by linear mixed-effects models. Linear mixed-effects models and ANOVAs were used to examine metabolomic changes associated with blood mercu

SUBMITTER: Feng M 

PROVIDER: S-EPMC12277391 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature