Impact of aging on cardiovascular dynamics and heart rate variability during passive head-up tilt.

ABSTRACT: During aging, arterial stiffness and blood pressure (BP) increase, while heart rate variability (HRV) decreases. We examined age-related hemodynamics in 522 individuals without cardiovascular disease during passive head-up tilt (HUT) using pulse wave analysis, whole-body impedance cardiography, and HRV analysis. Mean age was 44 years, body mass index 26 kg/m², and office BP 138/88 mmHg. Cardiac output was 7% higher in the youngest quartile than the oldest. With increasing age, aortic BP, pulse pressure, pulse wave velocity, wave reflection, and systemic vascular resistance increased, while heart rate, pulse pressure amplification, and aortic reflection time decreased. During HUT, aging was linked to greater reductions in systolic BP, pulse pressure, and stroke volume, as well as

SUBMITTER: Choudhary MK 

PROVIDER: S-EPMC12277527 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature