Intensive Blood Pressure Control in Patients With Diabetes and Previous Stroke: A Post-Hoc Analysis of ACCORD-BP Trial.

ABSTRACT: Intensive systolic blood pressure (SBP) control reduces cardiovascular outcomes in hypertensive patients, but its effects in those with diabetes and prior stroke need further evidence. Among 4733 patients with elevated SBP enrolled in the ACCORD-BP (Action to Control Cardiovascular Risk in Diabetes-Blood Pressure) trial, this post-hoc analysis focused on 307 patients with type 2 diabetes and prior stroke to evaluate intensive versus standard SBP control. The primary outcome was major adverse cardiovascular events (MACE), a composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke. Inverse probability of treatment weighting (IPTW)-adjusted Kaplan-Meier and Cox regression analyses were performed with a 3-year conditional landmark. Multivariable Cox regression mode

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12277531 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature