Effects of Sacubitril/Valsartan on Blood Pressure and Proteinuria in Hypertensive Patients With Chronic Kidney Disease.

ABSTRACT: The effects of the angiotensin receptor-neprilysin inhibitor sacubitril/valsartan (Sac/Val) on blood pressure (BP) and proteinuria in patients with advanced chronic kidney disease and hypertension remain unclear. This retrospective study evaluated the effect of Sac/Val on BP, the urinary protein-to-creatinine ratio (UPCR), and the estimated glomerular filtration rate (eGFR) in 66 patients with hypertension and proteinuria (UPCR ≥ 0.15 g/g) who received renin-angiotensin system inhibitors at 1, 3, and 6 months. At baseline, the median eGFR and UPCR were 28.4 mL/min/1.73 m² and 1.18 g/g, respectively. Significant reductions in systolic and diastolic BP, the eGFR, and the UPCR were observed over time (p values ranged from 0.03 to < 0.0001). At 1 month, 59% of patients showed a tran

SUBMITTER: Murakoshi M 

PROVIDER: S-EPMC12277533 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature