The Effect of 12-Week e-Cigarette Use on Smoking Abstinence at 1 Year: The E3 Trial.

ABSTRACT:

Background

The current evidence regarding the long-term efficacy of electronic cigarettes (e-cigarettes) for smoking cessation is unclear.

Objectives

The purpose of this study was to assess the efficacy, safety, and tolerability of nicotine and non-nicotine e-cigarettes for smoking cessation in the general population.

Methods

We randomized 376 adults who smoked ≥10 cigarettes/day and were motivated to quit at 17 Canadian sites to 12 weeks of nicotine (15 mg/mL) e-cigarettes (n = 128), non-nicotine e-cigarettes (n = 127), or no e-cigarettes (n = 121). All groups received individual counseling. The primary endpoint was point prevalence abstinence (7-day recall, biochemically validated using expired carbon monoxide) at 12 weeks. The 52-week follow-up results are reported

SUBMITTER: Filion KB 

PROVIDER: S-EPMC12277599 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature