Metabolic Syndrome Evolution and Cardio-Kidney-Metabolic Multimorbidity: Implications for Targeted Prevention.

ABSTRACT:

Background

Metabolic syndrome (MetS) is an important criterion for clinicians in assessing cardio-kidney-metabolic diseases, yet the association between longitudinal evolution of MetS and cardio-kidney-metabolic disease multimorbidity remains unclear.

Objectives

The purpose of this study was to investigate the extent of increased multimorbidity risk in individuals recovered from MetS and investigate the mediation of Life's Essential 8 (LE8) score on MetS transition patterns and risk of multimorbidity.

Methods

A cohort study using data from the Kailuan study (2006-2010) was conducted. Cox regression models were used to assess the association of MetS evolution with multimorbidity and its components. Survival mediation analysis was used to calculate the mediation proport

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12277610 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature