Association Between Life's Essential 8 and Cardiovascular, Cancer, and Other Cause Mortality: The REGARDS Study.

ABSTRACT:

Background

Cardiovascular disease (CVD) and cancer are leading causes of death in adults. Life's Essential 8 (LE8) estimates cardiovascular health (CVH) and includes body mass index, blood pressure, blood sugar, cholesterol, diet, physical activity, sleep, and smoking. CVD, cancer, and other mortality are competing risks.

Objectives

The purpose of this study was to determine the risk of CVD mortality, cancer mortality, and other mortality by LE8-quantified CVH in a competing risk framework.

Methods

REGARDS (REasons for Geographic and Racial Differences in Stroke) study recruited 30,239 Black and White adults from the 48 contiguous U.S. states from 2003 to 2007. We excluded prevalent CVD or cancer, missing LE8, or no follow-up. LE8 scores were categorized as low (<50),

SUBMITTER: Huether KM 

PROVIDER: S-EPMC12277625 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature