Sodium-Glucose Cotransporter Inhibition Preserves Apolipoprotein M During Acute Inflammation in Mice and Humans.

ABSTRACT:

Background

Sodium-glucose cotransporter inhibitors (SGLT2is) reduce inflammation and maintain vascular integrity. Apolipoprotein M (ApoM) is crucial for vascular integrity via sphingosine-1-phosphate (S1P) signaling and is inversely linked with mortality in sepsis and COVID-19.

Objectives

The authors tested if SGLT2i (dapagliflozin [Dapa]) increases ApoM in mice using lipopolysaccharide (LPS) and in humans with COVID-19.

Methods

Diet-induced obese mice (n = 14-15/group), proximal tubule-specific knockout of the multiligand protein receptor Lrp2 (Lrp2^KO) mice (n = 5-8/group), Ly6G-Cre LoxP-STOP-TdTomato mice (n = 3-5/group), Apom^KO mice (n = 3-5/group), and Apom^TG mice (n = 3-5/group) were randomized to receive either vehicle or Dapa (1

SUBMITTER: Valenzuela Ripoll C 

PROVIDER: S-EPMC12277633 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature