Genetic Insights Into the Link Between Restless Legs Syndrome and Diabetic Nephropathy Risk.

ABSTRACT:

Background

Restless legs syndrome (RLS) is a common neuro-sensory disorder associated with various metabolic diseases, including diabetes mellitus and its complications. Observational studies suggest a potential association between RLS and diabetic complications; however, the causal relationship remains unclear due to confounding factors and reverse causation. This study aims to assess the causal relationship between RLS and diabetes, including its complications, using a bidirectional Mendelian randomization (MR) approach.

Methods

Genetic instruments derived from the latest genome-wide association study (GWAS) data for RLS, Type 1 diabetes, Type 2 diabetes, and diabetic complications (diabetic nephropathy, diabetic retinopathy, and diabetic neuropathy) were selected on the b

SUBMITTER: Lin Y 

PROVIDER: S-EPMC12277665 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature