Identification and validation of DNA methylation-driven gene OSR1 as a novel tumor suppressor for the diagnosis and prognosis of breast cancer.

ABSTRACT:

Introduction

Aberrant DNA methylation plays a critical role in the initiation and progression of cancer, yet its association with breast cancer remains inadequately defined. This study aims to clarify the link between methylation-driven genes and breast cancer pathogenesis.

Methods

RNA sequencing and DNA methylation data for breast cancer were retrieved from The Cancer Genome Atlas (TCGA). Prognostically relevant methylation-driven genes were identified by integrating the methylation R package with univariate Cox regression analysis, and OSR1 emerged as the primary candidate. Gene expression profiles and corresponding clinical data were subsequently obtained from TCGA. Differential expression analysis using the Wilcoxon rank-sum test revealed significantly reduced OSR1 expre

SUBMITTER: Xu J 

PROVIDER: S-EPMC12277919 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature