Proteomic Signatures Underlying Sleep, Circadian Activity Patterns, and Major Chronic Diseases.

ABSTRACT: Rest-activity rhythm and sleep may serve as potential intervention targets for a variety of diseases. However, the underlying biological mechanisms of rest-activity rhythm, sleep, and their proteomic associations with multiple diseases remain largely unexplored. Here, using data from approximately 10 000 participants in the UK Biobank with accelerometer-derived measures and proteomics profiles, we characterized the proteomic signatures of rest-activity and sleep and explored their associations with health outcomes. We found that the proteins associated with rest-activity and sleep were mainly enriched in inflammation, immune response and complement system. Most rest-activity and sleep measures, along with their associated proteomic signatures, were significantly associated with incident di

SUBMITTER: Wei J 

PROVIDER: S-EPMC12277940 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature