Influence of the Gut Microbiota on Acute Ischemic Stroke Functional Outcomes at Three Months.

ABSTRACT:

Background

Functional recovery from ischemic stroke (IS), the main cause of adult disability worldwide, is influenced by many factors, and a portion of interindividual variability remains unexplained.

Methods

Observational study in a tertiary stroke centre of patients with IS analyzed using shotgun metagenomic sequencing (January 2020-March 2022). Functional outcomes were assessed according to modified Rankin Scale (mRS) scores 3-months post-IS, considering 0-2 favorable and 3-6 unfavorable. The causal relationship between several bacteria and post-IS outcomes was explored via two-sample Mendelian randomization (MR) analyses using Genome-Wide Association Analysis (GWAS) summary statistics.

Results

Comparing 128 patients with favorable and unfavorable post-IS functiona

SUBMITTER: Lledos M 

PROVIDER: S-EPMC12278021 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature