Phosphatemia is an Independent Prognostic Factor in Amyotrophic Lateral Sclerosis.

ABSTRACT:

Objective

The objective of this study was to evaluate the prognostic value of several muscle damage biomarkers.

Methods

Data from Piemonte and Valle d'Aosta Amyotrophic Lateral Sclerosis (PARALS) were considered for this study. Survival was defined as the time from diagnosis to death, tracheostomy, or the censoring date. Blood levels of potassium, creatinine, creatine kinase, phosphorus, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) diagnosis were evaluated as potential prognostic biomarkers. A Cox model was developed for each biomarker and adjusted for sex, onset age, onset site, and diagnostic delay. Significant findings from PARALS were evaluated in the Pooled Resource Open-Access Amyotrophic Lateral Sclerosis Clinical Trials (PRO-ACT) database. Addi

SUBMITTER: Vasta R 

PROVIDER: S-EPMC12278033 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature