Occupational exposures in sarcoidosis: a protocol for a multicentre regional case-control study in the UK.

ABSTRACT:

Background

Sarcoidosis is a multisystem granulomatous disease of unclear cause. An environmental trigger in a genetically susceptible individual resulting in immune dysregulation is suspected. More than 90% of cases of sarcoidosis involve the lungs, suggesting that inhaled environmental antigens contribute to the onset of disease. Many potential environmental antigens have been proposed to date, although equipoise persists concerning occupational exposures.The SANDSTONE study (Silica and Sarcoidosis: a study of Occupational Exposures) is the first UK-based study that investigates the association between occupational exposures and a diagnosis of pulmonary sarcoidosis, with particular focus on respirable crystalline silica, metal dusts, inorganic dusts and organic dusts.

Methods a

SUBMITTER: Huntley CC 

PROVIDER: S-EPMC12278141 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature