Application of protein A immunoadsorption in thyroid-associated ophthalmopathy (TAO): study protocol for a non-randomised controlled clinical trial.

ABSTRACT:

Introduction

Thyroid-associated antibodies are crucial in the occurrence and development of thyroid-associated ophthalmopathy (TAO). Protein A immunoadsorption is a more specific and plasma-independent antibody removal technology, which has been used in a variety of autoimmune diseases, such as systemic lupus erythematosus and antineutrophil cytoplasmic antibodies associated vasculitis (ANCA-associated vasculitis). This study protocol aims to verify the efficacy and safety of the application of protein A immunoadsorption in TAO to provide a new method for the treatment of this pressing disease.

Methods and analysis

This clinical trial is a single-centre, prospective, non-randomised controlled trial in China. 174 screened patients with moderate to severe active TAO will be di

SUBMITTER: Lu S 

PROVIDER: S-EPMC12278163 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature