Advances in the treatment of transthyretin amyloidosis.

ABSTRACT: This review aims to provide a comprehensive overview of the existing therapeutic options for managing neuropathic and/or cardiac manifestations associated with transthyretin amyloidosis (ATTR), along with investigational therapeutic candidates under evaluation in ongoing clinical trials. Additionally, emerging approaches for combating this life-threatening disease are discussed. Recent advancements in non-invasive diagnostic techniques for the detection of ATTR have facilitated improved diagnosis and identification at an earlier disease stage, thereby enhancing the potential efficacy of therapeutic interventions. Presently, there exists a range of clinically available treatments targeting ATTR, alongside investigational agents undergoing assessment in clinical trials. Therapeutic modalitie

SUBMITTER: Anan I 

PROVIDER: S-EPMC12278169 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature