Cholinergic Degeneration and Cognitive Function in Early GBA1-Related Parkinson's Disease.

ABSTRACT:

Objective

The phenotype of patients with Parkinson's disease carrying GBA1 variants (GBA-PD) suggest similarities to symptomatology associated with early cholinergic system degeneration. Therefore, this study aims to investigate the clinical features and the cholinergic innervation pattern in patients with early GBA-PD versus those without the GBA1 mutation (non-GBA-PD).

Methods

A total of 46 GBA-PD and 104 non-GBA-PD subjects were included. Clinical assessments included motor and non-motor evaluation, as well as a comprehensive neuropsychological examination. Cholinergic system integrity was assessed using ^{1 8}F-Fluoroethoxybenzovesamicol (¹⁸F-FEOBV) positron emission tomography (PET) to investigate the differences between GBA-PD and non-GBA-

SUBMITTER: Slingerland S 

PROVIDER: S-EPMC12278189 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature